ρ |
0.05 |
Empirical parameter characterizing strength of Wnt-induced Wnt and DKK production [a.u.]. |
μu
|
0.003 |
Wnt degradation rate [s−1] |
μv
|
0.008 |
DKK degradation rate [s−1] |
D |
100 |
Free diffusion coefficient [μm2 ⋅ s−1] |
k1
|
7.8 |
Adsorption rate constant [μM−1 ⋅ s−1] |
k−1
|
0.2 |
Desorption rate constant [s−1] |
w0
|
10 |
Volume binding site density [μM] |
u(t) |
0–0.1 |
Non-bonded WNT fraction [μM] |
u(t) + w0 − w(t) |
0–50 |
Total WNT fraction [μM] |
v(t) |
0–50 |
DKK concentration [μM] |
ρv
|
0.02–0.03 |
Permanent independent production of DKK [μM ⋅ s−1] |