Table 3. Multivariate survival analyses with COX model adjusting for all important covariates in a cohort of 238 patients with advanced HCC.
| Variables | P value | Hazard ratio (HR) | 95.0% CI* for Exp(B) | |
|---|---|---|---|---|
| Lower | Upper | |||
| Child Pugh Class | ||||
| A | 0.003 | Reference | ||
| B | 1.8 | 1.2 | 2.5 | |
| Eastern cooperative oncology group (ECOG) Performance status (PS) | ||||
| ECOG PS 0 | <0.0001 | Reference | ||
| ECOG PS 1 | 0.04 | 1.7 | 1.02 | 2.9 |
| ECOG PS > 1 | <0.0001 | 3.5 | 1.9 | 6.6 |
| Single HCC <5 cm | ||||
| No | 0.01 | Reference | ||
| Yes | 0.6 | 0.4 | 0.9 | |
| Extent and site of the portal or hepatic vein invasion | ||||
| No portal vein invasion | 0.010 | Reference | ||
| Small vein invasion | 0.04 | 1.4 | 1.01 | 2.2 |
| Large vein invasion | 0.002 | 2.02 | 1.3 | 3.2 |
| Extra-hepatic metastasis | ||||
| Absent | 0.04 | Reference | ||
| Present | 1.6 | 1.02 | 2.5 | |
| Serum Alpha Fetoprotein level > 400 ng/dl | ||||
| No | <0.0001 | Reference | ||
| Yes | 2.1 | 1.4 | 3.1 | |
| Serum Creatinine (mg/dl) ≥1.2 | ||||
| No | 0.009 | Reference | ||
| Yes | 1.8 | 1.2 | 2.7 | |
CI* = Confidence Interval.