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. 2016 Nov 18;31(3):882–892. doi: 10.1096/fj.201600969R

Figure 4.

Figure 4.

A, B) MicroCT reconstructions of WT, Scx-mutant, and BTX-WT mice at 14 d (A) and 28 d (B) (WT and Scx-mutant only) after fracture. Scx-mutant mice did not have robust callus formation on all surfaces of the femur. Administration of BTX to the quadriceps at the time of fracture did not alter the callus morphology. C) Fracture callus volume at d 14 was reduced in the Scx-mutant group and increased in the BTX-WT mice compared to WT. D) At d 28, the callus volume was reduced in the Scx-mutant group compared to WT. E, F) Callus bone volume (BV) at d 14 (E) and at d 28 (F) were lower in the Scx-mutant group vs. the WT. G–J) Callus BV/total volume (TV) (G, H) and bone mineral density (BMD) (I, J) were decreased in the BTX-WT mice compared to WT (G, I); callus density did not differ between WT and Scx-mutant mice at either healing time point (H, J). Bars indicate significant difference between groups; P < 0.05.