TABLE 1.
Mechanical testing of WT and Scx-mutant mice
| WT |
Scx-Mutant |
|
|---|---|---|
| Parameter | Average ± sd | Average ± sd |
| BW (g) | 25.44 ± 5.34 | 20.35 ± 3.17** |
| MicroCT and 3-point bending (femur) | ||
| TMD (mgHA/cm3) | 867.60 ± 34.40 | 841.60 ± 85.40 |
| Ct.Ar. (mm2) | 0.78 ± 0.13 | 0.72 ± 0.14 |
| I (mm) | 0.13 ± 0.04 | 0.11 ± 0.06 |
| Rigidity (N/mm2) | 579.20 ± 168.40 | 437.70 ± 121.50 |
| Yield load (N) | 9.26 ± 4.45 | 6.40 ± 2.10 |
| Maximum load (N) | 14.70 ± 5.09 | 11.50 ± 2.13 |
| PYD (mm) | 0.28 ± 0.19 | 0.13 ± 0.05* |
| Work-to-fracture (N/mm) | 4.72 ± 2.44 | 2.34 ± 0.77** |
| Young’s modulus (MPa) | 5061.00 ± 2603.00 | 4772.00 ± 1882.00 |
| Yield stress (MPa) | 95.20 ± 67.90 | 80.80 ± 44.40 |
| Maximum stress (MPa) | 145.40 ± 74.30 | 142.10 ± 51.30 |
| MicroCT and 3-point bending (ulna) | ||
| TMD (mgHA/cm3) | 839.50 ± 62.00 | 824.30 ± 29.50 |
| Ct.Ar. (mm2) | 0.31 ± 0.09 | 0.20 ± 0.03* |
| I (mm) (4) | 0.05 ± 0.01 | 0.03 ± 0.01* |
| Rigidity (N/mm2) | 57.56 ± 24.73 | 23.67 ± 3.58* |
| Yield load (N) | 1.69 ± 0.62 | 0.75 ± 0.35* |
| Maximum load (N) | 2.37 ± 0.72 | 1.34 ± 0.24** |
| PYD (mm) | 0.28 ± 0.10 | 0.41 ± 0.29 |
| Work-to-fracture (N/mm) | 1.04 ± 0.36 | 0.67 ± 0.24 |
| Young's modulus (MPa) | 12,814.00 ± 4413.00 | 9516.00 ± 3,854.00 |
| Yield stress (MPa) | 165.70 ± 43.70 | 123.50 ± 70.30 |
| Maximum stress (MPa) | 145.40 ± 74.30 | 142.10 ± 51.30 |
| Reference point indentation testing (tibia) | ||
| ID first (µm) | 86.50 ± 38.90 | 131.30 ± 22.80* |
| IDI (µm) | 23.30 ± 4.80 | 22.80 ± 2.90 |
| TID (µm) | 101.50 ± 38.10 | 141.50 ± 20.80 |
| US first (µm) | 0.17 ± 0.04 | 0.09 ± 0.01* |
| CID (µm) | 4.50 ± 1.35 | 6.88 ± 0.53** |
*
P < 0.05, **P < 0.01.