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. 2016 Nov 30;31(3):868–881. doi: 10.1096/fj.201600856R

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This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — IL-10–induced effects on regulation of HAS1-3 and HA-rich PCM are mediated via STAT3 signaling. A–C) Time course for mRNA expression of HAS1 (A), HAS2 (B), and HAS3 (C) in STAT3^−/− AFBs with or without IL-10 treatment. Bar plots represent means ± sd of 2 experiments. D, E) Pericellular HA coat assessment via particle exclusion assay in STAT3^−/− AFBs (D) and STAT3^−/− AFBs treated with IL-10 (E). F) PCM ratio and means ± sd of 3 experiments (20 cells analyzed per experiment) are shown for STAT3^−/− AFBs and STAT3^−/− AFBs treated with IL-10 (200 ng/ml) for 24 h. G) HA levels in culture medium of STAT3^−/− AFBs and STAT3^−/− AFBs treated with IL-10 (200 ng/ml) for 24 h. Means ± sd of 3 experiments (see also Supplemental Fig. S3). Scale bar, 50 μm. ns, not significant.