Table 1.

Mutations/rearrangements of histone writers and erasers in B-cell progenitor acute lymphoblastic leukemia (BCP-ALL).

Gene (Reference)	Histone-Modifying Function	Frequency of Mutations/Rearrangements in BCP-ALL	Subgroups Enriched
CREBBP [50,51,53,55,57]	H3K18 acetyltransferase (and other H3/H4 residues)	Rare in cases without hyperdiploidy and relapse	Relapse, hyperdiploidy
EP300 [50,55]	H3K18 acetyltransferase (and other H3/H4 residues)	<1%	-
MLL1 [3,5,6,82,122,123]	H3K4 methyltransferase	5%	-
NSD2 [44,91]	H3K36 methyltransferase	Not documented in unselected patients, up to 14% in subgroups	ETV6-RUNX1-rearranged
SETD2 [44,60,93,124]	H3K36 methyltransferase	12%	MLL- and ETV6-RUNX1- rearrangements, relapse
EZH2 [44,55,94]	H3K4 methyltransferase	1.3%	hypodiploidy
JAK2 [99,100,125,126]	H3Y41 phosphorylase	Not determined in unselected patients, up to 10% in high risk disease	BCR-ABL1-like, Down syndrome, high-risk disease