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. 2017 Jan 6;9(1):3. doi: 10.3390/cancers9010003

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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FACT stabilizes tailless nucleosomes. CTD and/or HMG domain(s) of SSRP1 are required for this activity. Effect of FACT_-N (A) and comparison of the effects of FACT_-N and FACT_-N(SSRPΔ) on tailless nucleosomes (B) as detected by spFRET microscopy. Typical frequency distributions of proximity ratios (E_PR) are shown. n is a number of analyzed nucleosomes.