Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model of FACT action during nucleosome stabilization. Histone tail removal results in destabilization of nucleosomes accompanied by partial uncoiling of the nucleosomal DNA. On a small fraction of the templates, nucleosomes are dramatically unfolded. The three transitions in the structure of the nucleosomes are reversible and likely require the presence of CTD domains on both FACT subunits; CTD removal blocks the transitions.
