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. 2017 Jan 16;9(1):9. doi: 10.3390/cancers9010009

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mutual regulatory model of miRNAs and androgen receptor (AR). The graphic also shows MRX-34, the first miRNA based therapy for cancer. BBC3: Bcl-2-binding component 3; IGF1R: Insulin-like growth factor 1; Bak1: Bcl-2 homologous antagonist/killer 1; HER2: human epidermal growth factor receptor 2; p57Kip2: cyclin-dependent kinase inhibitor; AP-1: activator protein 1; STAT3: signal transducer and activator of transcription 3; HMGA: high mobility group A gene; PCAF: p300/cAMP-response element-binding protein associated factor; PI3K: phosphatidylinositol-3-kinases; PlncRNA-1: prostate cancer-up-regulated long noncoding RNA 1.