Table 3.
Stromal produced paracrine factors. Proliferative effect (P), Differential effect (D) supported by [97,99,100]. Androgen regulation (Y = yes, regulated by androgen, N = no, not regulated by androgen) determined from microarray data from [12,45,87].
| Paracrine Factor | Effect | Androgen Regulation |
|---|---|---|
| CTGF | P | Y |
| FGF (2, 5, 7, 8, 9, 10) | P, D | Y (2, 5, 7), N (8), N/A (9, 10) |
| HGF | P, D | Y |
| IGF (1, 2) | P, D | Y (1, 2) |
| IL-6 | P | Y |
| PDGF | P, D | Y |
| TGFb (1, 2, 3) | P, D | Y (1, 2, 3) |
| VEGF (A, B, C) | P | Y (A,C), N (B) |
| WNT | P | Y |
| CXCL12 | P | N |
| EGF | P, D | N/A |
| TGFa | P, D | N/A |