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. 2017 Feb;58(2):781–796. doi: 10.1167/iovs.16-20611

Figure 1.

Figure 1

Bone morphogenetic protein-7 application inhibits TGFβ2-induced EMT in a dose-dependent manner. Following 48 hours of culture, untreated control explants (A) retained a normal cuboidal layer of epithelial cells, whereas cells in explants treated with TGFβ2 alone (B) displayed an elongate, spindle-shaped morphology (yellow arrows). Cotreatment with TGFβ2 and 1 ng/ml BMP-7 ([C], +TB1) also resulted in elongate cells (yellow arrows), whereas higher doses of BMP-7 (5, 10, and 50 ng/ml; +TB5, +TB10, +TB50) retained the normal lens epithelial phenotype (D–F). Images are representative of 3 independent experiments. Scale bar: 100 μm.