Figure 12.

Bone morphogenetic protein-7 inhibits TGFβ2-induced suppression of Id2 and Id3 gene expression. Using RT-qPCR, treatment with TGFβ2 alone significantly downregulated expression of Id2 and Id3 compared to control explants. The addition of BMP-7 significantly inhibited TGFβ2-induced suppression of Id2 and Id3 showing no significant difference to control explants for Id2 and Id3. Data from 4 independent experiments are presented relative to GAPDH as fold change ± SEM. Unpaired t-test *P < 0.05, **P < 0.01, ***P < 0.001.