Table 1.
Characteristic |
nab-P + Gem (n=38) |
Gem (n=38) |
All patients in Western Europe (n=76) | ITT population (N=861)* |
---|---|---|---|---|
Age, median (range), years | 59.5 (37–77) | 66.0 (42–80) | 63.0 (37–80) | 63.0 (27–88) |
≥65 years, % | 29 | 61 | 45 | 42 |
Male, % | 53 | 39 | 46 | 58 |
KPS, % | ||||
90–100 | 74 | 82 | 78 | 60 |
70–80 | 24 | 18 | 21 | 40 |
Primary tumor location, % | ||||
Head | 39 | 27a | 33 | 43 |
Body | 47 | 49a | 48 | 31 |
Tail | 13 | 24a | 19 | 25 |
Site(s) of metastasis, % | ||||
Liver | 87 | 84 | 86 | 84 |
Lung | 24 | 45 | 34 | 39 |
No of metastatic sites, % | ||||
1 | 8 | 8 | 8 | 6 |
2 | 53 | 47 | 50 | 47 |
≥3 | 39 | 45 | 42 | 46 |
Previous Whipple, % | 0 | 5 | 3 | 7 |
Biliary stent, % | 8 | 8 | 8 | 17 |
Notes:
Evaluable n=37.
From N Engl J Med, Von Hoff DD, Ervin T, Arena FP, et al, Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine, 69, 1691–1703. Copyright © (2013) Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.8
Abbreviations: Gem, gemcitabine; ITT, intention-to-treat; KPS, Karnofsky performance status; nab-P, nab-paclitaxel.