Table 4.

Proteomics studies of chemoresistance in OS

Model	Treatment	Techniques	Year	Citation
OS cell lines: HS-Os-1, NOS-1, SaOS-2, SJSA-1, 143B, HOS, HuO9, KHOS/NP, MG-63, MNNG-HOS, and NOS-10	Doxorubicin	2D-DIGE, annotated mass spectra in Genome Medicine Database of Japan Proteomics	2013	Arai et al57
Frozen tissue: poor responders (<90% necrosis), good responders (>90% necrosis)	Methotrexate, doxorubicin, and cisplatin	2D-DIGE, Orbitrap mass spectrometer	2013	Kubota et al58

Abbreviations: OS, osteosarcoma; 2D-DIGE, two-dimensional difference gel electrophoresis.