Table 3.
Multivariable logistic regression analysis for association between cytokine and symptoms at baselinea
| Cytokine (natural logarithm transformed) as independent variable | No. of patients | Dependent variable = severe depression
|
Dependent variable = severe fatigue
|
||
|---|---|---|---|---|---|
| Adjusted OR (95% CI) | p-Value | Adjusted OR (95% CI) | p-Value | ||
| EGF | 79 | 1.57 (0.93, 2.65) | 0.09 | 1.17 (0.73, 1.85) | 0.51 |
| IFN-γ | 80 | 1.45 (1.08, 1.94) | 0.013 | 1.16 (0.90, 1.48) | 0.25 |
| IL-1 | 63 | 0.98 (0.60, 1.60) | 0.93 | 0.71 (0.43, 1.17) | 0.18 |
| IL-1β | 68 | 1.35 (0.92, 1.99) | 0.13 | 0.88 (0.63, 1.24) | 0.47 |
| IL-1Ra | 63 | 1.62 (1.07, 2.45) | 0.022 | 1.57 (1.04, 2.36) | 0.033 |
| IL-6 | 80 | 1.45 (1.07, 1.96) | 0.015 | 1.02 (0.79, 1.32) | 0.87 |
| IL-8 | 83 | 1.85 (1.23, 2.79) | 0.003 | 0.98 (0.72, 1.32) | 0.88 |
| TGF-α | 79 | 1.57 (1.08, 2.28) | 0.019 | 1.09 (0.80, 1.50) | 0.58 |
| TNF-α | 81 | 1.79 (1.21, 2.66) | 0.004 | 1.02 (0.75, 1.40) | 0.90 |
| VEGF | 82 | 1.75 (1.07, 2.86) | 0.027 | 1.20 (0.79, 1.82) | 0.39 |
Notes:
a
A multivariable logistic regression model was fit for each symptom to estimate the adjusted OR for each cytokine. In these models, the same set of adjusting covariates was included for all cytokines.
Abbreviations: CI, confidence interval; EGF, epidermal growth factor; IFN-γ, interferon-γ; IL, interleukin; OR, odds ratio; TGF-α, transforming growth factor-α; TNF-α, tumor necrosis factor-α; VEGF, vascular endothelial growth factor.