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Overview of the treatment options of hepatitis C virus-associated pruritus. Once the underlying factors [elevated concentration of lysophosphatidic acid (LPA), pro-inflammatory cytokines, chemokines] causing pruritus have been determined, the treatment strategy can be based on the reduction of the pain or neutralization of the elevated concentration of LPA, pro-inflammatory cytokines and chemokines using local anesthetics, anti-inflammatory drug, Opioids or alpha2 agonists.
