Table 3.
Association between demographics and hepatitis B virus viral load in 303 hepatitis B surface antigen-positive relatives n (%)
| Factor |
HBV DNA |
OR (95%CI) | P value | Adjusted OR (95% CI)1 | P value | |
| ≥ 100000 cps/mL | < 100000 cps/mL | |||||
| Total family members | 132 | 171 | ||||
| Sex | ||||||
| Male | 84 (63.64) | 79 (46.20) | 2.12 (1.34-3.39) | 0.0013 | ||
| Female | 48 (36.36) | 92 (53.80) | ||||
| Index sex | ||||||
| Male | 99 (75) | 121 (70.76) | 1.83 (0.69-2.04) | 1.17 (0.68-2.01) | ||
| Female | 33 (25) | 50 (29.24) | ||||
| Age, mean ± SD | 40.51 ± 12.18 | 39.15 ± 10.55 | 1.01 (0.99-1.03) | 1.02 (0.99-1.04) | ||
| Relation to index | ||||||
| Child and grandchild | 83 (62.88) | 128 (74.85) | ||||
| Parent | 7 (5.30) | 2 (1.17) | 4.77 (1.12-20.31) | 0.0348 | 4.57 (1.15-18.14) | 0.0307 |
| Index generation | 42 (31.82) | 41 (23.98) | 1.51 (0.87-2.62) | 0.64 (0.36-1.14) | ||
| Maternal HBsAg | ||||||
| Negative | 33 (25) | 51 (29.82) | ||||
| Positive | 61 (46.21) | 64 (37.43) | 1.55 (0.84-2.87) | 1.57 (0.84-2.92) | ||
| Unknown | 38 (28.79) | 56 (32.75) | 1.08 (0.57-2.06) | 1.20 (0.62-2.33) | ||
| Index HBsAg | ||||||
| Negative | 12 (9.16) | 32 (18.93) | ||||
| Positive | 119 (90.84) | 137 (81.07) | 2.32 (1.13-4.76) | 0.0221 | 2.47 (1.19-5.15) | 0.0158 |
| HBV genotype2 | 0.0017 | |||||
| N3 | 2 (1.53) | 21 (12.88) | 0.11 (0.03-0.44) | 0.09 (0.02-0.39) | 0.0011 | |
| B | 97 (74.62) | 120 (73.62) | ||||
| C | 31 (23.85) | 22 (13.50) | 1.71(0.94-3.14) | 0.008 | 1.80 (0.97-3.36) | 0.0640 |
1
Adjusted by sex;
2
There are 10 missing HBV genotypes;
3
Genotyping failed due to low HBV DNA. HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen.