Table 5.
Intra-family comparison of hepatitis B virus viral load among hepatitis B surface antigen-positive siblings n (%)
| HBV DNA level1 |
Maternal HBsAg |
Total | ||
| Positive | Unknown | Negative | ||
| Total male siblings | 12 | 9 | 7 | 28 |
| All high level | 7 (58.33)2 | 2 (22.22) | 2 (28.57) | 11 (39.3)3 |
| All low level | 1 (8.33)2 | 2 (22.22) | 1 (14.29) | 4 (14.3)3 |
| Older > younger | 3 (25.00) | 3 (33.33) | 3 (42.86) | 9 (32.1) |
| Younger > older | 1 (8.33) | 1 (11.11) | 1 (14.29) | 3 (10.7) |
| Other | 0 (0.00) | 1 (11.11) | 0 (0.00) | 1 (3.6) |
| Total female siblings | 11 | 3 | 4 | 18 |
| All high level | 2 (18.18)2 | 0 (0.00) | 0 (0.00) | 2 (11.1)3 |
| All low level | 6 (54.55)2 | 1 (33.33) | 3 (75.00) | 10 (55.6)3 |
| Older > younger | 1 (9.09) | 1 (33.33) | 0 (0.00) | 2 (11.1) |
| Younger > older | 1 (9.09) | 0 (0.00) | 1 (25.00) | 2 (11.1) |
| Other | 1 (9.09) | 1 (33.33) | 0 (0.00) | 2 (11.1) |
1
Low HBV DNA level, < 1 × 105 cps/mL; high HBV DNA level, ≥ 1 × 105 cps/mL.
2
OR (95%CI) = 21 (1.50-293.25), P = 0.024;
3
OR (95%CI) = 29.96 (2.54-353.17), P = 0.007; logistic regression. HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen.