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. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Dev Cell. 2017 Jan 26;40(3):313–322.e5. doi: 10.1016/j.devcel.2016.12.022

Figure 3. related to Figure S4. Centrosome amplification drives aneuploidy in vivo.

Figure 3

(A) Proportion of severely aneuploid (4N ± > 2 chromosomes) splenocytes from control and Plk4Dox mice treated with doxycycline for 1 or 8 months. N = 3, > 120 cells per experiment.

(B) Table shows the fraction of aneuploid cells determined by single cell sequencing of epidermal cells from doxycycline-treated control or Plk4Dox mice.

(C) Genome-wide copy number plots of aneuploid single cells sequenced from the epidermis of 3 Plk4Dox mice treated with doxycycline for 12–18.5 months. Individual cells are represented in rows with copy number states indicated in colors.

All data represent the means ±SEM. *P < 0.05; two-tailed Student’s t-test. Scale bars represent 10 μm.