Table 1.

Inhibition constants for SAP inhibitors.

Compound	Construct	Inhibition constant $K_{\mathrm{i}}^{\ast }$(nM)a
2	PDpDIApGpPD	3.3 ± 0.2
3	GpDIApGpPD	10.5 ± 0.9
4	GpDIApGpA	6.1 ± 0.3
23	DIApGpPD	10,700 ± 800
25	PDpGpDIApGpPD	7.4 ± 0.4
30	DIApG	21,300 ± 800
32	GpDIApG	33.0 ± 1.7
33	PDpDIApG	19.3 ± 1.7
39	PDpGpDIApPD	188 ± 12
41	GpGpDIApPD	212 ± 17
45	PDpDEIApGpPD	12.4 ± 0.9
52	PDpHomoSerpGpPD	26.8 ± 0.3
	PDpSerpGpPD	43.2 ± 1.1b
	PDpApGpPD (substrate analogue)	16,000 ± 1500

^a $K_{\mathrm{i}}^{\ast }$ is the dissociation constant K_d for the inhibitor interactions with SAP following slow–onset inhibition.

^bValues taken from Schramm et al. [19].