Table 3.

Statistical associations (Spearman correlation coefficient) between MZ and the constituent items and total scores of the established weekly questionnaires (ASRM, QIDS, GAD-7, EQ-5D).

		MZ items						MZ factors
		Anxious	Elated	Sad	Angry	Irritable	Energetic	Negative	Positive	Irritability
ASRM	Happy	0.08	0.26	0.07	0.07	0.11	0.19	0.06	0.26	−0.06
	Confident	0.09	0.26	0.05	0.08	0.12	0.19	0.06	0.26	−0.04
	Sleep	0.18	0.16	0.15	0.18	0.24	0.08	0.18	0.17	−0.01
	Talkative	0.16	0.21	0.14	0.15	0.20	0.11	0.16	0.21	−0.06
	Active	0.14	0.21	0.12	0.13	0.15	0.19	0.12	0.24	−0.06
QIDS	Sleep	0.38	−0.08	0.33	0.31	0.34	−0.13	0.39	0	−0.02
	Sad	0.65	−0.01	0.76	0.55	0.53	−0.16	0.71	0.08	−0.30
	Appetite/weight	0.46	−0.02	0.39	0.35	0.39	−0.17	0.46	0.02	−0.09
	Concentration	0.59	−0.09	0.56	0.46	0.49	−0.23	0.61	−0.02	−0.18
	Self-view	0.59	−0.03	0.63	0.45	0.46	−0.18	0.62	0.04	−0.25
	Suicide	0.47	−0.06	0.56	0.41	0.39	−0.17	0.53	0.01	−0.16
	Interest	0.52	−0.07	0.57	0.41	0.43	−0.20	0.56	0	−0.18
	Energy	0.54	−0.12	0.55	0.39	0.42	−0.27	0.57	−0.06	−0.21
	Restless	0.57	−0.04	0.55	0.44	0.49	−0.15	0.60	0.05	−0.15
GAD-7	Nervous/anxious	0.72	0	0.64	0.53	0.55	−0.16	0.69	0.08	−0.25
	Control worries	0.67	0	0.66	0.54	0.53	−0.14	0.67	0.1	−0.24
	Worried	0.69	0.01	0.66	0.54	0.54	−0.13	0.67	0.11	−0.25
	Relaxed	0.68	−0.02	0.62	0.51	0.55	−0.15	0.67	0.08	−0.22
	Restless	0.54	0.09	0.50	0.44	0.45	−0.04	0.54	0.16	−0.15
	Irritable	0.63	0.07	0.58	0.61	0.69	−0.12	0.67	0.16	0
	Afraid	0.67	−0.04	0.67	0.54	0.54	−0.17	0.68	0.07	−0.2
EQ-5D		−0.58	0.15	−0.55	−0.46	−0.50	0.37	−0.63	0.11	0.09
Total	ASRM	0.19	0.26	0.16	0.17	0.22	0.17	0.17	0.27	−0.07
	QIDS	0.67	−0.05	0.69	0.53	0.56	−0.22	0.71	0.03	−0.23
	GAD-7	0.77	0.03	0.72	0.61	0.65	−0.15	0.77	0.13	−0.23

Bold entries indicate statistically strong associations (Spearman $\left|R\right|\ge 0.3$). All entries with $\left|R\right|\ge 0.1$ were statistically significant ($p<0.0001$). We used the nine QIDS domains rather than the 16 items, because depression is clinically assessed in this way. Each of the items of the weekly questionnaires is presented as a sentence to participants; we present these as words here to facilitate comparisons. The MZ factors were determined using the PCA loadings computed in Table 2.