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Bile duct ligation induces transcriptional reprogramming in PiZZ mouse liver. (A, B). Western blot of nuclear proteins showing decreased nuclear C/EBP-α and C/EBP-β isoforms in BDL livers compared to sham-operated and wild-type (WT) control liver. Nuclear FXR is decreased after BDL at later time points. Nuclear TFEB is not significantly changed in BDL and sham livers. TATA-binding protein (TBP) serves as the nuclear protein-loading control.
