Figure 5.

Partial bile duct ligation induces localized ATZ globule clearance in PiZZ mouse liver. (A) Serum ALT, alkaline phosphatase, and total bilirubin levels in mice 14 days after pBDL are comparable to age- and sex-matched unoperated PiZZ (control) mice. As expected, biochemical parameters in BDL mice (shown in Fig. 1A) are significantly worse compared to pBDL values. (B) Quantitative results of ATZ globule morphometry showing decreased percentage of PASD globules present in the ligated left lobe (pBDL) compared to the unligated right control lobe. (C) PASD staining showing the cleared areas of ATZ globules in pBDL (ligated left lobe, right) compared to control (unligated right lobe, left). Arrows point to residual GC hepatocytes intermixed within areas of ductal proliferation, similar to total BDL (magnification: 200×).