Figure 2.
Pevonedistat induces apoptosis in melanoma cell lines. The most sensitive cell lines based on their IC50s from the cell viability assay were selected for study. Cell lines were treated with various concentrations of pevonedistat for 24 hrs and evaluated for level of apoptosis using the Caspase-Glo® 3/7 assay. Results of representative cell lines are shown, expressed as fold-increase in apoptosis compared to vehicle control. Treated groups were compared to the untreated group (vehicle) by unpaired T-test, with statistically significant differences indicated by asterisks (* if p<0.05, ** if p<0.005).