Figure 1.
Chronic consumption of a western diet is associated with hyperphagia. Male mice maintained for 60 days on a western diet (Western) become obese (a, cumulative change in body weight; b, gross body weight) and display increases in 24 h caloric intake, meal size, and rate of intake (c–e) when compared to mice maintained on a standard chow diet (Stand). Meal duration, frequency, and post meal interval do not significantly differ between diets (f–h). Repeated measures two-way ANOVA, with Sidak’s multiple comparison post hoc test, *** = p<0.001 (a); unpaired Student’s t-test (two-tailed), *** = p<0.001 between Stand and Wetern. Results are expressed as means ± SEM; n=16/condition (a, b), n=8/condition (c–h).