Table 1. Steady-State Peak and Trough Levels of Approved DOACs.
| Drug | Dose | Time to Peak | Median Peak (5th to 95th percentile) |
Median Trough (5th to 95th percentile) |
References |
|---|---|---|---|---|---|
| Dabigatran | 150 mg BID | 1–2 hours | 184 ng/mL (64–443) |
90 ng/mL (31–225) |
4, 16 |
| Rivaroxaban | 20 mg daily | 2–4 hours | 270 ng/mL (189– 419) |
26 ng/mL (6–87) |
6, 34 |
| Apixaban | 5 mg BID | 3–4 hours | 171 ng/mL (91–321) |
103 ng/mL (41–230) |
5, 36 |
| Edoxaban | 60 mg daily | 1–2 hours | 170 ng/mL (120–250)a |
22 ng/mL (10–40)a |
7, 11 |
a
Interquartile range