Serum basic diagnostics and blood count |
Normal renal, liver, and thyroid values;
Slightly increased C3d concentration (11.1 mg/l; reference value <9 mg/l);
Normal blood count.
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Serum autoantibody analyses |
Normal thyroid autoantibodies (against thyroglobulin, thyroid peroxidase, and thyroid-stimulating hormone);
Rheumatological screening: increased antinuclear antibodies (titer: 1:400; reference value <1:50) without clear extractable nuclear antigens; the anti-nucleosome antibodies were weakly positive;
No antibodies against intracellular onconeural antigens (Yo, Hu, CV2/CRMP5, Ri, Ma1/2, SOX1), or the intracellular synaptic antigens (GAD, amphiphysin).
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Cerebrospinal fluid (CSF) analyses |
Normal white cell count, no blood–brain barrier dysfunction (normal protein concentration and albumin quotient);
No CSF-specific oligoclonal bands, but a weak identical band in the CSF and serum;
Antibodies against neuronal cell surface antigens [NMDAR, AMPA-R, GABA-B-R, VGKC complex (LGI1, Caspr2)] were negative.
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Cerebral magnetic resonance imaging (1.5 T) |
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Electroencephalography (during the first admission to our clinic in 2013, under the treatment with clozapine, aripiprazole, and citalopram) |
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