Figure 5.

BMP9 treatment reduced neuroinflammation in APP/PS1 mice. (A) Brain sections of the cortex and hippocampus were stained with anti-Iba1. Bar = 100 μm. (B) The proportions of Iba1-positive area were calculated. (C) Brain sections of the cortex and hippocampus were stained with anti-glial fibrillary acidic protein (GFAP). Bar = 100 μm. (D) The proportions of GFAP-positive area were calculated. (E) The transcripts of cytokines and chemokines in the brains of APP/PS1 mice treated with vehicle or BMP9 were measured by quantitative RT-PCR. Values are represented as the mean ± SD. Student’s t test or ANOVA followed by Bonferroni’s post hoc test. *p < 0.05, n = 6.