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. 2017 Feb 8;8:20. doi: 10.3389/fendo.2017.00020

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Copyright © 2017 Bandyopadhyay and Mahata.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic depiction of the domains of the chromogranin A (CgA) protein. Relative locations of vasostatin (VS1), pancreastatin (PST), WE14, catestatin (CST), and serpinin domains in CgA have been illustrated along with the description of their basic functional properties. (B) PST homology in mammals. Clustal-W program of MacVector (version 9.0) was used for PST domain alignments across 26 mammalian species. PST amino acid domains were shown on the left and percentage homology as compared to human sequence (100%) was shown on the right. The following gene accession numbers were used for this analysis: human (J03483), chimpanzee (XM_510135), western lowland gorilla (XM_004055595), northern white-cheeked gibbon (XM_003260903), olive baboon (NC_018155.1), rhesus monkey (XM_001092629), crab-eating macaque (AB_169793), Bolivian squirrel monkey (XM_003939842), white-tufted-ear marmoset (XM_002754214), small-eared galago (XM_003786997), Norway rat (XM_346781), house mouse (NM_007693), Chinese hamster (NW_003614307), dog (XM_003639191), cat (XM_003987967), Pacific walrus (XM_004394490), horse (NM_001081814), southern white rhinoceros (XM_004434217), cow (NM_181005), pig (XM_001925714), sheep (XM_004017959), killer whale (XM_004262352), bottle-nosed dolphin (XM_004315772), Florida manatee (XM_004376681), nine-banded armadillo (XM_004475519), and Tasmanian devil (XM_003756143). -, gaps in the alignment.