Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Feb 8;8:65. doi: 10.3389/fimmu.2017.00065

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 Thomas and Tampé.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of the tapasin (Tsn)–major histocompatibility complex class I (MHC I) interaction. Cartoon representation of the predicted Tsn–MHC I complex, based on multi-microsecond all-atom MD simulations, for which the crystal structures of the lumenal portions of Tsn and HLA-B*44:02 were used as starting models (40, 55). There are two distinct interfaces, one between the N-terminal (distal) domain of Tsn and the α_2-1-helix region of the MHC I heavy chain (MHC I hc) (A), the other between the membrane-proximal domain of Tsn and the α₃ domain of the MHC I hc (B). Residues predicted to be part of the interfaces are shown as sticks in the close-up views. β2m, β2-microglobulin.