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Import regulation of the TIC complex from the stromal site. Similar to the redox regulation at the OEM import of precursor proteins is accelatered under reducing conditions, suggestively due to an open conformation of the main channel, Tic110. A second regulation mechanism involves the stromal redox state, which is reflected by the NADPH/NADP+ ratio. A low NADPH/NADP+ ratio could be shown to enhance the import rate compared to a higher NADPH/NADP+ ratio.
