FIG 4 .

Functional analysis of the distal gut microbiota metagenomes. (A) Differences in specific functional categories between Egyptian and U.S. gut microbiota. Each category comprises several SEED level 3 entries, each represented as individual bars with results calculated as log₂-transformed ratios of reads between egkHLT and uskHLT metagenomes. All displayed entries are statistically significant, with FDR-corrected P of <0.01. (B) Relative abundances of specific metabolites and the mean log₂ ratios of reads of metabolic enzymes that produce and/or utilize the metabolites are compared. CoA/P, coenzyme A/phosphate.