TABLE 3 .
Nonsynonymous SNPs in known drug resistance genes detected in Plasmodium vivax samples that underwent selective whole-genome amplification (SWGA)
| Locus | Chromosome | Position | Reference allelea | Alternate alleleb | Amino acid changec | No. of samples bearing indicated allele(no. confidently genotyped) |
|---|---|---|---|---|---|---|
| pvcrt-0 (PVX_087980) | 1 | 331151 | T | C | Intron | 17 (18) |
| 331819 | G | A | Intron | 11 (18) | ||
| 332453 | T | C | Intron | 18 (18) | ||
| 332874 | A | C | Intron | 18 (18) | ||
| pvdhfr (PVX_089950) | 5 | 964763 | C | G, A | Ser58Arg | 12 (12) |
| 964939 | G | A | Ser117Asn | 16 (16) | ||
| pvmdr1 (PVX_080100) | 10 | 363223 | A | G | Thr958Met | 12 (12) |
| 363374 | T | G | Met908Leu | 11 (11) | ||
| 365435 | C | A | Val221Leu | 1 (12) | ||
| pvmrp2 (PVX_124085) | 14 | 2043859 | G | C | Gln1407Glu | 11 (13) |
| 2045050 | C | T | Val1010Met | 14 (15) | ||
| 2047090 | G | A | Pro330Ser | 1 (15) | ||
| 2047233 | C | A | Arg282Met | 13 (14) | ||
| 2047816 | C | G | Glu88Gln | 3 (18) | ||
| dhps (PVX_123230) | 14 | 1257856 | G | C | Ala383Gly | 9 (15) |
| 1258389 | C | T | Met205Ile | 10 (12) |
a
Allele of the P. vivax Sal-1 reference genome at the indicated position.
b
Allele found in P. vivax samples from Peru that underwent SWGA.
c
Amino acid change resulting from base change from the reference to the alternate allele.