FIG 6 .
Pathway proposed for anaerobic CH4 oxidation (ANME) by M. acetivorans. The reaction numbers are shown in parentheses in the figure. CoA-SH, coenzyme A; H4SPT, tetrahydrosarcinapterin; FdxR, reduced ferredoxin; FdxO, oxidized ferredoxin; HSCoM, coenzyme M; HSCoB, coenzyme B; MP, methanophenazine; HdrDE, membrane-bound heterodisulfide reductase; HdrA2B2C2, cytoplasmic heterodisulfide reductase; Rnf, Rnf complex; Cyt c, cytochrome c; Atp, ATP synthase; Mrp, sodium/proton antiporter; Mtr, membrane-bound methyltransferase. Enzymes and thermodynamic calculations for each reaction are shown in Table S2.