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. 2017 Feb 1;8:14053. doi: 10.1038/ncomms14053

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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HOPX methylation levels were determined via bisulfite pyrosequencing analysis. Kaplan–Meier analysis was performed to determine the DMFS, OS and DFS according to the HOPX methylation level (low methylation versus high methylation) in NPC patients. (a–c) DMFS (a), OS (b) and DFS (c) in 255 NPC patients in the training set. (d–f) DMFS (d), OS (e) and DFS (f) in 188 NPC patients in the validation set. Adjusted univariate Cox proportional hazard models were used to calculate the HR values and P values.