Table 1. PPIX and griseofulvin concentrations used in the in vitro parasite growth inhibition experiments and determined in the IBSM study.

Study (subject sample)	[PPIX] (μM)	[Griseofulvin] (μg/L)	[Griseofulvin] (μM)	PPIX:Griseofulvin molar ratio
In vitro	0.16		50	1:313
In vitro	0.8		50	1:63
In vitro	1.6b		50	1:31
In vitro	4b		50	1:13
IBSM (I6)a	0.08c	767d	2.17	1:27
IBSM (I7)a	0.12c	747d	2.12	1:18

^aPlasma sample collected on study Day 7 in IBSM Cohort 2.

^bComplete blockade of griseofulvin parasiticidal activity observed at these PPIX concentrations (determined in Fig. 2b).

^cPPIX concentrations determined by HPLC MS-MS (Supplementary Fig. S5).

^dPlasma griseofulvin concentration (determined in Fig. 4c).