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. 2017 Feb 8;7:42123. doi: 10.1038/srep42123

Figure 1. Structures of TOP3β, TDRD3 and the TOP3β–TDRD3 complex.

Figure 1

(a) Domain organizations of TOP3β and TDRD3. Thick dashed lines represent molecular interactions. (b) Overall structure of the TOP3β–TDRD3 complex. (c) Overall structure of the TOP3α–RMI1 complex. The close-up view shows the interaction between the C-terminal helix of TOP3α and the insertion loop of RMI1. (d) Catalytic pocket of apo TOP3β. The bound magnesium ion and its coordinated water molecules are shown as yellow and grey spheres, respectively. (e) Expected pivot points of TOP3β and TOP3α in the TOP3β–TDRD3 and TOP3α–RMI1 complexes, respectively. The coloring scheme is the same as that of (b,c).