Figure 3. High resolution accessibility mapping of the promoter structure at U6.
High resolution NOMe-seq map at U6-1 (Type III gene, external promoter) in K562, RKO, IMR90 and HL60 cells. Teal circles represent accessible GpC/CpC sites, white inaccessible. If regions of consecutive inaccessible sites equal or exceed 146 bp, we indicate the region as being occupied by a nucleosome (pink bars). Orange bars indicate regions of inaccessibility shorter than 146 bp, i.e. footprints, here at the TTS. The TATA box is indicated by a purple box, PSE by blue and DSE by green. Red line indicates TTS. Dotted line indicates the junction between the two separate PCR fragments analyzed.