Table 3. Patterns of failure in each patient subgroup.
| Pattern of failure | Failure No. (%) | Infield | Marginal | Outfield | CSF seeding only |
|---|---|---|---|---|---|
| No. (%*) | |||||
| All patients (n = 167) | 118 (71%) | 82 (69%) | 30 (26%) | 19 (16%) | 5 (4%) |
| Subgroups (according to prognostic factors) | |||||
| GTR (n = 78) | 50 (64%) | 34 (68%) | 12 (24%) | 13 (28%) | 3 (6%) |
| MGMT methylation (n = 59) | 37 (63%) | 22 (59%) | 10 (27%) | 10 (27%) | 4 (11%) |
| GTR + MGMT methylation (n = 33) | 17 (52%) | 8 (47%) | 5 (29%) | 6 (36%) | 1 (6%) |
| GTR + MGMT methylation + Age < 60-year (n = 16) | 7 (44%) | 3 (43%) | 2 (28%) | 4 (57%) | 0 |
| Subgroups (according to RT target volume) | |||||
| Edema (+) RT (n = 130) | 88 (68%) | 66 (76%) | 19 (22%) | 16 (18%) | 3 (3%) |
| Edema (−) RT (n = 37) | 30 (81%) | 16 (53%) | 11 (37%) | 3 (10%) | 2 (7%) |
| Subgroups (according to prognostic factors & RT target volume) | |||||
| GTR & edema (+) RT (n = 57) | 33 (58%) | 26 (46%) | 6 (11%) | 10 (18%) | 3 (9%) |
| GTR & edema (−) RT (n = 21) | 17 (81%) | 8 (38%) | 6 (29%) | 3 (14%) | 4 (19%) |
| MGMT methylation & edema (+) RT (n = 43) | 27 (63%) | 19 (70%) | 6 (22%) | 7 (26%) | 3 (11%) |
| MGMT methylation & edema (−) RT (n = 16) | 10 (63%) | 3 (30%) | 4 (40%) | 3 (30%) | 1 (10%) |
| GTR + MGMT methylation & edema (+) RT (n = 19) | 7 (37%) | 5 (71%) | 1 (14%) | 3 (43%) | 0 |
| GTR + MGMT methylation & edema (−) RT (n = 14) | 10 (71%) | 3 (30%) | 4 (40%) | 3 (30%) | 1 (10%) |
Abbreviations: GTR = gross total resection; MGMT = O6-methyl-guanine-DNA methyltransferase; RT = radiotherapy; CSF = cerebrospinal fluid.
*% in all failures (Not the % in all patients).