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. Author manuscript; available in PMC: 2017 Feb 8.
Published in final edited form as: Clin Cancer Res. 2015 Sep 15;22(2):470–478. doi: 10.1158/1078-0432.CCR-15-0715

Figure 5.

Figure 5

Association of HLA class I antigen and PD-L1 expression in primary ICC lesions with OS in patients with ICC. A, the OS of patients with lesions grouped based on AJCC stage system was compared using the Kaplan–Meier method. Stage group of ICC lesions is indicated. Differences in patients' survival were analyzed using a log-rank test. B, the OS of patients with lesions stained with a positive HLA class I antigen expression in combination with negative/rare PD-L1 expression and that of lesions with high PD-L1 expression (PD-L1 score ≥ 2), negative/heterogeneous HLA class I antigen expression or a combination of both were compared using the Kaplan–Meier method. Differences in patients' survival were analyzed using a log-rank test. C, patients were stratified on HLA class I antigen expression as those with positive or negative/heterogeneous ICC. Then the OS of patients with lesions stained with high PD-L1 expression (PD-L1 score ≥2) was compared with that of patients with negative/rare PD-L1 expression using the Kaplan–Meier method. Differences in patients' survival were analyzed using a log-rank test.