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. 2017 Feb 7;24:12. doi: 10.1186/s12929-017-0320-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — JAB1 silencing attenuates the oxLDL-induced expression and secretion of TNF-α and IL-6. PMA-differentiated human U937 MΦ were treated (4 h) with 50 μg/ml oxLDL and compared to the control (medium). TNF-α (a) and IL-6 (c) mRNA expression levels were determined using RT-qPCR. TNF-α (b) and IL-6 (d) protein secretion was determined using ELISA. Bars represent mean ± SEM of 3 independent experiments. *p < 0.05 significance vs. control, ^# p < 0.05 significance vs. non-transfected MФ or nsiJAB1-MФ