Fig. 2.

Sustained growth signaling in mammary gland tumor tissue of chronically insulin analogue exposed mice. a The INSR/IGF1R signaling pathway with receptors, downstream targets, and the biological effect. b Hierarchical clustering (Euclidian distance) of the INSR/IGF1R-specific gene expression per MG tumor. The pie diagrams show the distribution of the different treatments in the two clusters. c Bar graph of SVM simulation on the predicted proliferation potential per treatment of MG tumors of the chronically exposed mice (i) and human breast cancer cells (MCF7 IGF1R) exposed for 1 h to the indicated insulin analogue (ii). *P < 0.05. ns not significant