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. 2017 Feb 7;5:4. doi: 10.1186/s40364-017-0083-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic diagram summarizing functional relevance of metastatic signals in synovial sarcoma. SYT-SSX fusion is a founding event in the development of this cancer which frequently results in the production of molecular signals that promote tumor metastasis. Abbreviations: Akt (Serine/threonine kinase); CDCA2 (Cell division cycle A2); CXCR (Chemokine receptor); ERK1/2 (Extracellular signal-regulated kinase 1/2); EZH2 (Enhancer of zeste homologue 2); IGFBP7 (Insulin-like growth factor-binding protein-7); IGR (Insulin like growth factor receptor); KIF14 (Kinesin family member 14); MAPK (Mitogen-activated protein kinases); MicroRNAs (miRNAs); MMPs (Matrix metalloproteinases); mTOR (Mammalian target of rapamycin); NY-ESO-1 (New York esophageal squamous cell carcinoma 1); PI3K (Phosphatidylinositol-3-kinase); pri-miRNA (primary microRNA); pre-miRNA (precursor microRNA); PKB (Protein kinase B); RAS (Ras GTPase); SCRN1 (Secernin-1); TGF-β (Transforming growth factor beta); TβR (TGF-beta receptor); TF (transcription factor)