Table 1.
Association of clinical characteristics and 7-day mortality in the cohort
| Non Survivors | Survivors | p value | |
|---|---|---|---|
| (n = 84) | (n = 102) | ||
| Age (years), mean ± SD | 67 ± 16 | 70 ± 13 | 0.14 |
| Male sex, n (%) | 42 (50%) | 62 (61%) | 0.14 |
| Medical condition, n (%) | 57 (68%) | 50 (49%) | 0.01 |
| Primary site of infection, n (%) | |||
| Pulmonary | 49 (58%) | 55 (54%) | 0.55 |
| Urinary | 6 (7.1%) | 9 (8.8%) | 0.68 |
| Abdominal | 8 (9.5%) | 12 (12%) | 0.62 |
| BSI a | 14 (17%) | 15 (15%) | 0.71 |
| CRBSI b | 5 (6.0%) | 11 (1%) | 0.24 |
| SSTIs c | 2 (2.4%) | 0 | 0.20 |
| Comorbidities, n (%) | |||
| Heart failure | 28 (33%) | 50 (49%) | 0.03 |
| Coronary artery disease | 25 (30%) | 42 (41%) | 0.11 |
| Pulmonary disease | 8 (9.5%) | 10 (9.8%) | 1.0 |
| Liver failure | 55 (66%) | 32 (31%) | <0.001 |
| Cerebral vascular disease | 7 (8.3%) | 8 (7.8%) | 0.90 |
| Diabetes | 23 (27%) | 37 (36%) | 0.20 |
| Norepinephrine use | 78 (93%) | 80 (78%) | 0.006 |
| Admission creatinine (mg/dl), median (IQR) | 1.0 (0.8–1.6) | 1.2 (0.9–2.2) | 0.14 |
| Laboratory values before RRT d, median (IQR) | |||
| Urea (mg/dl) | 142 (86–198) | 137 (78–206) | 0,57 |
| Chloride (mmol/l) | 109 (104–112) | 107 (104–110) | 0,41 |
| Creatinine (mg/dl) | 2.2 (1.5–3.3) | 2.7 (2.0–3.8) | 0.005 |
| Potassium (mmol/l) | 4.7 (3.8–5.4) | 4.3 (3.8–5.0) | 0.05 |
| Sodium (mmol/l) | 133 (127–137) | 135 (132–139) | 0.009 |
| Lactate (mmol/l) | 3.0 (1.8–5.1) | 1.8 (1.4–2.7) | <0.001 |
| Hemoglobin (g/dl) | 8.9 (8.0–9.9) | 9.1 (8.2–10) | 0.21 |
| White cell count (103 mm3/l) | 17 (6.6–24) | 16 (11–22) | 0.64 |
| Platelets count (103 mm3/l) | 94 (48–176) | 155 (79–265) | 0.001 |
| 24 h urinary output (ml/kg/h) | 320 (150–600) | 300 (100–600) | 0.57 |
| Fluid Balance (ml) | 7782 (4175–11,389) | 6891 (4090–9692) | 0.007 |
a BSI bloodstream infections
b CRBSI cateter-related bloodstream infections
c SSTIs skin and soft tissue infections
d RRT renal replacement therapy