Table 2.

Epigenome-wide associations between genome-wide DNA methylation and lipid levels

				Discovery		Replication
	CpG site	Chromosome	Position	Regression coefficient	p a	Regression coefficient	p a	Gene
Triglycerides	cg00574958	11	68607622	−0.0206	1.23 × 10 −15	−0.0114	7.24 × 10 −13	CPT1A
	cg06500161	21	43656587	0.0149	5.02 × 10 −11	0.0201	1.46 × 10 −15	ABCG1
	cg11024682	17	17730094	0.0135	3.40 × 10 −10	0.0172	3.27 × 10 −11	SREBF1
	cg17901584	1	55353706	−0.0162	1.56 × 10 −08	−0.0068	9.54 × 10−02	DHCR24
	cg17058475	11	68607737	−0.0183	9.84 × 10 −08	−0.0118	1.71 × 10 −06	CPT1A
HDL-C	cg06500161	21	43656587	−0.0202	1.84 × 10 −12	−0.0189	3.29 × 10 −12	ABCG1
	cg14816825	11	12128203	−0.0143	6.31 × 10 −08	−0.0051	1.15 × 10−01	NA b
	cg17901584	1	55353706	0.0196	6.44 × 10 −08	0.0142	1.03 × 10 −03	DHCR24

Models are adjusted for age, gender, current smoking, leukocyte proportions, array number, and position on array

Values are regression coefficients based on linear mixed models and reflect differences in methylation beta values per increase in HDL-C or log-transformed triglyceride unit

^a P values in italic indicate statistical significance. Level of significance: p < 1.08 × 10⁻⁰⁷(discovery cohort), p < 7.14 × 10⁻⁰³(replication)

^bNot annotated