Table 3.

Associations between genome-wide DNA methylation and lipid levels (meta-analyses)

		Model 2a		Model 3b		Model 4c
	ProbeID	Regression coefficient	p d	Regression coefficient	p d	Regression coefficient	p d	Gene
TG	cg00574958	−0.0142	2.6 × 10 −26	−0.0114	1.9 × 10 −16	−0.0161	1.5 × 10 −22	CPT1A
	cg06500161	0.0167	1.4 × 10 −24	0.0153	3.9 × 10 −18	0.0151	7.0 × 10 −14	ABCG1
	cg11024682	0.0147	3.0 × 10 −19	0.0124	8.4 × 10 −13	0.0138	1.0 × 10 −11	SREBF1
	cg17058475	−0.0146	3.1 × 10 −13	−0.0120	8.8 × 10 −09	−0.0196	9.2 × 10 −16	CPT1A
	cg17901584	−0.013	1.9 × 10 −08	−0.0104	2.5 × 10 −05	−0.012	2.5 × 10 −05	DHCR24
HDL-C	cg06500161	−0.0187	9.5 × 10 −23	−0.0166	9.5 × 10 −16	−0.0116	2.5 × 10 −07	ABCG1
	cg14816825	−0.0104	3.2 × 10 −07	−0.0145	3.8 × 10 −07	−0.0127	1.7 × 10 −07	NA e
	cg17901584	0.0164	2.4 × 10 −09	0.0128	1.3 × 10 −05	0.0116	3.6 × 10 −04	DHCR24

All models are adjusted for age, gender, current smoking, leukocyte proportions, array number, and position on array

Values are regression coefficients based on linear mixed models and reflect differences in methylation beta values per increase in HDL-C or log-transformed triglyceride unit

^aModel 2: model 1 + lipid-lowering medication use

^bModel 3: model 1 + waist circumference

^cModel 4: model 1 + other lipids

^d P values in italic indicate statistical significance. Level of significance: p < 7.14 × 10⁻⁰³

^eNot annotated