Table 2.

Univariate and Multivariate Predictors of Change in NIHSS from Baseline to Day 3-5

	Univariate Analyses				Multivariate Model 1				Multivariate Model 2
	ΔNIHSS				ΔNIHSS R2 =0.44				ENR vs. ENS+END R2 = 0. 38
	β	95% CI	P value		adjusted β	95% CI	P value		adjusted OR	95% CI	P value
Age	0.027	−0.078 - 0.13	0.61
Admission Glucose	5.96	2.07 - 9.85	0.055		3.54	−0.57 - 7.66	0.09
Admission DWI	3.04	0.40 - 5.67	0.0043**		−0.83	−4.31 - 2.65	0.66
Infarct Growth	2.53	0.76 - 4.30	0.01*		0.02	−0.02 - 0.05	0.33		0.93	0.26 - 3.6	0.91
Swelling	0.11	0.071 - 0.15	<0.0001***		0.10	0.02 - 0.17	0.007**		0.94	0.88 - 0.98	0.014*
PH	−2.71	−4.6 - -0.82	0.0055**		−1.26	−2.98 - 0.46	0.15		0.26	0.012 - 2.3	0.27
Reperfusion	2.6	1.3 - 4.0	0.0001***		1.37	0.05 - 2.69	0.043*		4.1	1.2 - 17	0.036*

Admission glucose and admission DWI volume were log transformed before inclusion in Multivariate Model 1. Data are from the Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET) cohort. ΔNIHSS indicates the change in NIHSS score from baseline to day 3-5; CI, confidence interval; DWI, diffusion-weighted imaging; ENR, early neurological recovery; ENS, early neurological stability; END, early neurological deterioration; PH, presence of parenchymal hemorrhage 1 or 2; reperfusion, >90% reduction in perfusion-weighted imaging deficit volume between baseline and day 3-5.

^*p<0.05;

^**p<0.01;

^***p<0.001