White matter integrity reductions in schizophrenia with and without covarying for cognition. Without covarying for cognitive impairment, white matter integrity, inferred from fractional anisotropy (FA), was reduced in multiple brain areas in schizophrenia at both conservative (p<.05; Panel A) and liberal statistical thresholds (p<.10; Panel B). Similar results were observed after covarying for working memory, verbal fluency, delayed recall, and, to a lesser extent, verbal learning. In contrast, no group differences were observed after covarying for processing speed at either the conservative or liberal statistical thresholds. Statistical parametric maps (i.e. warm colors) are overlaid on the skeletonized FA map (i.e. green).