Table 2.

Prostate cancer results related to comparisons (one-tailed p-values) using the kernel-based approach (left) and the Box-Cox approach (right). Comparisons for scenario (1) are considered for FPR values of 0.05, 0.10 and 0.20. Comparisons for scenarios (2) and (3) are considered for TPRs=0.80, 0.85 and 0.95.

	Kernel-based				Box-Cox
Scenario (1)	TPRs:	0.80	0.85	0.95	TPRs:	0.80	0.85	0.95
	FPRs (PSA):	0.5895	0.6768	0.8648	FPRs (PSA):	0.6003	0.7072	0.9272
	FPRs (model):	0.4024	0.4749	0.6897	FPRs (model):	0.3697	0.4419	0.6687
	p-values:	< 0.0001	0.0003	0.0003	p-values:	< 0.0001	< 0.0001	< 0.0001
Scenario (2)	TPRs:	0.80	0.85	0.95	TPRs:	0.80	0.85	0.95
	FPRs (PSA):	0.5564	0.6422	0.8324	FPRs (PSA):	0.5513	0.6511	0.8846
	FPRs (model):	0.2836	0.3586	0.5993	FPRs (model):	0.2481	0.3173	0.5654
	p-values:	< 0.0001	< 0.0001	< 0.0001	p – values:	< 0.0001	< 0.0001	< 0.0001
Scenario (3)	FPRs:	0.05	0.10	0.20	FPRs:	0.05	0.10	0.20
	TPRs (PSA):	0.1446	0.2339	0.3930	TPRs (PSA):	0.1780	0.2797	0.4312
	TPRs (model):	0.3837	0.5141	0.6724	TPRs (model):	0.3951	0.5381	0.7031
	p-values:	< 0.0001	< 0.0001	< 0.0001	p-values:	< 0.0001	< 0.0001	< 0.0001

Scenario (1): Diseased defined by Gleason score ≥7. Healthy defined by Gleason score < 7.

Scenario (2): Diseased defined by Gleason score ≥7. Healthy defined by negative biopsy (Gleason score = 0).

Scenario (3): Diseased defined by Gleason score >0. Healthy defined by negative biopsy (Gleason score = 0).