Table 4.

Change in binding of rhumAbs to immobilized recombinant rat, cynomolgus monkey, and human FcRn proteins at pH 6.0 in the presence of 0.05 M NaCl.

	Binding response change (%)
Species of FcRn	rhumAb1	rhumAb2
Rat	−22	−79
Cynomolgus monkey	−40	−77
Human	−43	−76

Notes: Binding changes are expressed in terms of the FcRn binding response of rhumAb in the presence of additional 0.05 M of NaCl relative to the response obtained without additional salt in the running buffer. Each binding response was reported 5 seconds before the end of each injection. All data were corrected by in-line reference subtraction followed by buffer sample subtraction.